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General approach: If on Semaglutide 0.5 mg or less: Start tirzepatide at 2.5 mg If on Semaglutide 1.0 mg: Start tirzepatide at 5 mg If on Semaglutide 1.7-2.4 mg: Start tirzepatide at 5-7.5 mg Some providers start everyone at 2.5 mg regardless of previous dose to minimize side effects

10.1007/s12350-019-01624-z 26 PradhanR.LuS.YinH.YuO

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Unlike a standard 2.5 mg or 5 mg start, microdosing may begin as low as 0.25 mg